The deal is just the second in the UK between a university and Nike Team Sports, and includes bespoke kit for all teams, a comprehensive online sport and leisurewear range and new staff uniforms.
Barry Squires, Head of Sport at the university, said: "The first thing that came to mind was how unique this opportunity was. We are proud of the partnership with Nike and look forward to working with them"
"Nike understands how we want to be represented, that feeling you get when you see the kit and feel proud to wear the Panther shirt."
Initially announced at the 2020 University of Brighton Sports Awards, the partnership has now come to life with the launch of the online webshop.
The online store features the new bespoke leisurewear and training range with competitive playing kit being launched in the new year.
The sportswear giant already has a close association with the city as the official technical partner of Premier League club and university neighbours, Brighton & Hove Albion FC.